Assessment of exposure to toxic metals and elementsMonitor natural route of metal detoxification in infantsConvenient specimen collection procedureResult specific commentary providedAnalysis by ICP-MS
Analysis of elements in feces provides a comprehensive evaluation of environmental exposure, potential for accumulation in the body (Hg), and possibly endogenous detoxification of potentially toxic metals. For many toxic elements such as mercury, cadmium, lead, antimony and uranium, biliary excretion into the feces is the primary natural route of elimination from the body. The primary process by which the body eliminates the insidious sulfhydryl reactive metals is through the formation of metal-glutathione complexes, of which greater than 90% are excreted into the bile. Evidence for the extent of exposure to mercury from dental amalgams is provided by the fact that fecal mercury levels are highly correlated with the number of amalgams in the mouth. It also clear that fecal mercury levels for people with dental amalgams are remarkably similar from day to day, and approximately ten times higher than in people who do not have mercury amalgams.
Administration of pharmaceutical metal binding agents results in excretion of toxic metals primarily through the kidneys into the urine. In contrast, support of natural detoxification processes enhances the rate of excretion of toxic metals into the feces. Elemental analysis of fecal specimens can provide a valuable tool to monitor the efficacy of natural detoxification of metals in infants or patients who are on very limited and defined diets that do not contain contaminated solid foods.
A primary objective of preventive medicine is avoidance or removal of exposure to toxic substances. The rate of oral absorption of toxic metals varies considerably among elements, and among subspecies of a particular element. Fecal elemental analysis can provide a direct indication of dietary exposure. Orally, the percent absorption of nickel, cadmium and lead is usually quite low, but varies significantly in part due to the relative abundance of antagonistic essential elements in the diet. That is particularly evident for lead and calcium, and cadmium and zinc. Chronic, low-level assimilation of the toxic metals can result in significant accumulation in the body. The results of fecal elemental analysis can help identify and eliminate dietary exposure to toxic metals.
The fecal metals test was not developed to replace the pre and post urinary toxic metals provocation test, but rather provides an alternative for infants, children or adults for whom urine collection is problematic, or for individuals who do not tolerate the available pharmaceutical metal detoxification agents. Elements are measured by ICP-MS and expressed on a dry weight basis to eliminate variability related to water content of the specimen.
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